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(SAR.L) Sareum Holdings PLC Buy/Sell
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| Date/Time | Headline | Source |
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| 02-11-09 | RNS |
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RNS Number : 6860B Sareum Holdings PLC 02 November 2009 (AIM: SAR) 2 November 2009
SAREUM HOLDINGS PLC ("Sareum" or the "Company") Sareum to Present at BIO-Europe 2009 Sareum (AIM: SAR), the specialist cancer drug discovery business, is pleased to announce that Dr Tim Mitchell, CEO, will present Sareum's cancer drug discovery pipeline at BIO-Europe 2009 later today. BIO-Europe, being held this year in Vienna, Austria, is Europe's largest biotechnology partnering event. Dr Mitchell's presentation is part of the UK Showcase, an International Seminar introduced by UK Trade & Investment.
Sareum Holdings plc
Merchant John East Securities Limited
Hybridan LLP
Notes for editors: About Sareum Holdings plc Sareum is a drug discovery company, headquartered in Cambridge UK, that is focused on producing targeted small molecule therapeutics to address unmet medical needs, primarily in cancer. Sareum aims to successfully deliver drug candidates for licensing to pharmaceutical and biotechnology companies at the pre-clinical or early clinical trials stage. Sareum Holdings plc joined the AIM market of the London Stock Exchange in October 2004, trading under the symbol SAR. For further information, please visit www.sareum.co.uk This information is provided by RNS The company news service from the London Stock Exchange END
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| 30-10-09 | RNS |
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RNS Number : 6036B Sareum Holdings PLC 30 October 2009 30 October 2009 Sareum Holdings Plc ("the Company") Total Voting Rights The Company announces that, pursuant to the requirements of the Disclosure and Transparency Rules, the total number of voting rights in respect of each class of share in issue and admitted to trading on AIM at the date of this announcement is as follows:
each Enquiries:
Sareum Holdings plc
Merchant John East Securities Limited
Hybridan LLP
This information is provided by RNS The company news service from the London Stock Exchange END
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| 27-10-09 | RNS |
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This news article is displayed preformatted as it may contain results tables
RNS Number : 4019B
Sareum Holdings PLC
27 October 2009
27 October 2009
SAREUM HOLDINGS PLC
("Sareum" or the "Company")
FINAL RESULTS FOR THE YEAR ENDED 30 JUNE 2009
Sareum (AIM: SAR), the specialist cancer drug discovery business, is pleased to announce its final results for the year ended 30 June 2009.
Operational highlights:
* Strategic review and restructuring completed
* Relocation of office premises, resulting in significant cost savings
* On track with the development of cancer research programmes
* Three further patent applications filed
Financial highlights:
* Loss on ordinary activities for period (after taxation): £1.1 million (2008: £1.7 million), includes one-off re-structuring costs of £0.36 million
* Cash in bank at period end: £0.27 million (2008: £0.48 million)
Post year end highlights:
* Placings to raise £815,000 (before expenses)
* Based on current working capital requirements cash resources are sufficient for the foreseeable future
* Progress in Chk1 programme announced at NCRI cancer conference in early October
Dr Paul Harper, Chairman of Sareum, said: "The Company now focuses all its research resources on its pipeline of anti-cancer programmes. We have established a world-wide network of quality research providers and progress on the programmes is on-track and in-line with their budgets.
The strategic review of the business, completed at the beginning of this period, resulted in the sale of Sareum's service business and associated assets. In parallel with this review, the Company made major cost savings through staff reductions and closure of its laboratories.
We are actively talking to third parties who have shown interest in one or more of our oncology programmes. The most advanced of these is the Chk1 programme carried out in conjunction with the Institute of Cancer Research and Cancer Research Technologies Limited. This is a programme that attracts broad interest since it is focused upon potentiating the efficacy of a variety of marketed cancer chemotherapeutics, opening the possibility of better patient outcomes or of lower drug dosages to reduce toxicity.
The recent fund raisings will support increased investment in the development of our in-house programmes and satisfy our working capital requirements for the foreseeable future."
For further information please contact:
Sareum Holdings plc
Tim Mitchell, Chief Executive Officer 01223 497700
Merchant John East Securities Limited
Simon Clements/Bidhi Bhoma 020 7628 2200
Hybridan LLP
Claire Noyce/Stephen Austin 020 7947 4350
Final Results for the year ended 30 June 2009
Chairman and Chief Executive's Statement
Background
The key value creator for Sareum's shareholders is the development and commercialisation of drug candidates from the Company's in-house drug development pipeline.
Progress within Sareum's in-house research programmes, which focus on treatments for cancer, has been to plan. This includes successful in-vivo efficacy studies resulting from its collaboration with the Institute of Cancer Research and Cancer Research Technology Limited. Additionally, in the period under review three further patent applications have been filed to protect families of promising compounds arising from Sareum's research programmes.
At the start of the period, the Company completed its strategic review, initiated in May 2008, which resulted in the sale of its service business to Galapagos NV in August 2008. In addition, other equipment assets were sold and the Company's laboratories were closed. Alongside this, the company undertook a major cost and staff reduction programme. Whilst it was a difficult decision to make the positions of our talented and dedicated staff redundant, the Directors believe that a minimal fixed cost base is essential to the success of the re-structured Company.
The Company's strategy, following its re-structuring, is to concentrate primarily on its in-house cancer drug discovery research. This is achieved by outsourcing the chemistry and biology components of each programme. As before, our in-house expertise and experience is used to interpret the relationship between chemical structure and biological activity associated with each of the compounds tested. This leads to the design of new molecules which should be more active and more specifically targeted. Now that we have closed the Company's laboratories the synthesis and testing of new compounds is undertaken in third party laboratories.
As the development programmes progress and additional data is generated, demonstrating the quality of the candidate molecules, a very active campaign continues to draw these results to the attention of companies seeking to licence programmes such as these. In addition, as our research is presented from time-to-time at various conferences and seminars, we also receive some direct approaches from potential licensing partners.
Progress with In-House Cancer Targets
The Company's principal asset following the sale of the fee for service business is its intellectual property derived from its cancer drug discovery programmes. Sareum has seven drug discovery programmes and is actively developing three of them at the present time. The Company is engaged in discussions with a number of potential commercial partners involving several of these programmes. The Company has continued to make positive progress with its in-house cancer drug discovery programmes, resulting in three further patent applications and the publication of three patents from historic filings.
Sareum's pipeline is built on the expertise of its founders in pre-clinical drug discovery, particularly in the field of cancer. Sareum concentrates its research on targeted small molecule therapeutics.
Targeted cancer therapies disrupt specific biochemical processes necessary for tumour growth and survival. Because these processes are specific to cancer cells, targeted therapies may be more effective than other types of treatments, such as chemotherapy and radiotherapy, and less harmful to normal cells. Some targeted therapies, for instance Chk1 inhibitors, are designed to boost the efficacy of chemotherapy. Others, such as Aurora, FLT4 or FLT3 inhibitors, have the potential to be effective by themselves or in combination with chemotherapy or other targeted therapies.
Small molecule therapeutics (as opposed to "biological" drugs such as antibodies) are able to penetrate into the interior of a cell and thus can be targeted at the full range of processes in a biochemical pathway. Small molecule anti-cancer therapeutics can be designed to target one or more of a wide range of biochemical processes essential to cancer cells. Small molecule therapeutics also have the potential of being able to be administered orally (e.g. as a pill) rather than by injection.
Our strategy is to focus on developing best in class cancer therapies, where pre-clinical and early clinical data is available to indicate that disrupting the targeted biochemical process will indeed prevent tumour growth and survival without significant side-effects. We can capitalise on these published results to direct our own programmes and to indicate, for instance, whether or not the therapy needs to be administered in combination with additional cancer therapies.
Cancer cells differ from normal cells in many different ways. In particular, cancer cells divide and grow much more rapidly than normal cells. Biochemical processes targeted by Sareum that control cell growth and division include Checkpoint Kinase 1 (Chk1), Aurora Kinase (Aurora), FMS-like Tyrosine Kinase 3 (FLT3), Polo-Like Kinase (PLK) and B-raf.
Once a solid tumour reaches a certain size, it needs to be connected to the body's blood and lymph systems to receive nutrients and remove waste. Sareum's programme targeting Fms-like Tyrosine Kinase 4 (FLT4, sometimes referred to as Vascular Endothelial Growth Factor Receptor 3 Kinase, VEGFR-3) is importantly involved in the generation of new blood and lymph vessels to a tumour. FLT4 is also involved in the control of metastasis, the spread of cancer, which is the main cause of death in cancer patients.
Chk1 Kinase
This is Sareum's most advanced in-house programme and is carried out in conjunction with one of the world's leading cancer research organisations, The Institute of Cancer Research and Cancer Research Technologies Limited. Significantly, we have obtained results from in-vivo pre-clinical experiments that demonstrate a two-fold increase in the efficacy of marketed cancer chemotherapeutics when combined with programme compounds.
Aurora Kinase and FLT4 Kinase
These programmes are currently wholly-owned by the Company. In both cases we have developed drug candidates that are suitable for testing in in-vivo efficacy experiments. These studies are ongoing and we aim to report their progress at international cancer conferences during the next period.
Earlier-Stage Programmes (FLT3, FASN, PLK1, B-raf)
These programmes are currently on hold, pending a collaborative research deal with a pharmaceutical company partner or receipt of a research grant. FLT3, in addition to being a potential target for certain leukaemias, also has the potential to treat auto-immune diseases such as multiple sclerosis and rheumatoid arthritis, which further expands the commercial opportunities for this programme.
Changes to the Board
Dr Alastair Riddell (Non-Executive Director), Giorgio Reggiani (Finance Director) and Dr David Williams (VP, Biology & Structural Sciences) resigned from the Board of the Company during the period. We thank them for their valuable contribution to the Company and wish them well for the future.
Financial Review
During the period, revenues of £32,000 were recognised arising from fee-for-service collaborations prior to the sale of that part of the business.
The loss after taxation decreased to £1.1 million (2008: £1.7 million). This included one-off re-structuring costs of £360,000 and partially reflects the cost cutting measures resulting from the strategic review. The loss after taxation for the second half of the period was approximately £250,000 and this figure broadly translates to the working capital requirements of the Company for that six month period. The cash position at the period end was £0.27 million (2008: £0.48 million). Since the year end the cash position has been significantly improved following the share placings, announced in September and October 2009, that raised £815,000 before expenses. As a result of these placings, the Directors believe the Company is able to increase its R&D spend to further advance its cancer drug pipeline whilst also providing sufficient working capital for the foreseeable future
Summary
Despite difficult economic conditions and the sale of its fee for service business, the Company has demonstrated that it is able to progress its in-house research by advancing programmes according to plan and by working with our partners to develop candidate drug molecules.
The first half of this period was a difficult one for the Company, but demonstrated the capability of the Board to act decisively in the face of adverse market conditions.
The Directors believe the Company's strategy has been further endorsed by the participation of those investors that have subscribed for new shares in the Placings completed after the period end.
Outlook
The Company has an exciting opportunity to focus solely on its in-house cancer drug discovery programmes, to generate shareholder value. The research work for the ongoing programmes is being provided via third parties, leaving the Company with a much reduced fixed cost base.
The Company will continue to build value from its in-house research and development by seeking to advance its cancer drug discovery programmes. With sufficient cash resources to fund the ongoing business plan for the foreseeable future, the Company looks forward to further development and commercialisation of these cancer drug programmes.
Dr Paul Harper Dr Tim Mitchell
Chairman Chief Executive Officer
CONSOLIDATED INCOME STATEMENT
FOR THE YEAR ENDED 30 JUNE 2009
2009 2008
£ £
REVENUE
Discontinued operations 31,600 1,502,507
OPERATING EXPENSES
Continuing operations (1,170,007) (2,938,480)
Discontinued operations (14,669) (580,307)
(1,184,676) (3,518,787)
OPERATING PROFIT/(LOSS)
Continuing operations (1,170,007) (2,938,480)
Discontinued operations 16,931 922,200
(1,153,076) (2,016,280)
Finance costs (3,092) (36,236)
Finance income 14,436 32,927
LOSS BEFORE TAX (1,141,732) (2,019,589)
Tax 67,860 327,232
LOSS FOR THE YEAR (1,073,872) (1,692,357)
Loss per share expressed
in pence per share:
Basic (0.13p) (0.28p)
Diluted (0.13p) (0.27p)
There are no recognised gains or losses other than as stated in the Income Statement.
CONSOLIDATED BALANCE SHEET
AS AT 30 JUNE 2009
2009 2008
£ £
NON-CURRENT ASSETS
Intangible assets 1,575 25,836
Property, plant and equipment 1,170 723,843
2,745 749,679
CURRENT ASSETS
Trade and other receivables 33,619 283,702
Tax receivable 67,860 324,570
Cash and cash equivalents 273,977 480,851
375,456 1,089,123
LIABILITIES
CURRENT LIABILITIES
Trade and other payables 51,639 224,322
Financial liabilities - borrowings
Interest bearing loans and borrowings - 88,390
51,639 312,712
NET CURRENT ASSETS 323,817 776,411
NON-CURRENT LIABILITIES
Financial liabilities - borrowings
Interest bearing loans and borrowings - 125,656
NET ASSETS 326,562 1,400,434
SHAREHOLDERS' EQUITY
Called up share capital 204,524 204,524
Share premium 5,401,631 5,401,631
Merger reserve 27 27
Retained earnings (5,279,620) (4,205,748)
TOTAL EQUITY 326,562 1,400,434
CONSOLIDATED CASH FLOW STATEMENT
FOR THE YEAR ENDED 30 JUNE 2009
2009 2008
£ £
Cash flows from operating activities
Cash used in operations (1,035,382) (1,847,123)
Interest paid (3,092) (36,236)
Tax received 324,570 198,103
Net cash used in operating activities (713,904) (1,685,256)
Cash flows from investing activities
Purchase of intangible fixed assets - (6,500)
Purchase of tangible fixed assets (351) (83,065)
Sale of tangible fixed assets 706,991 -
Interest received 14,436 32,927
Net cash from/(used in) investing activities 721,076 (56,638)
Cash flows from financing activities
Repayment of leasehold improvements loan (34,830) (26,472)
Capital element of finance leases (179,216) (138,009)
Share issue - 89,572
Share premium on issue of shares - 1,637,328
Net cash (used in)/from financing activities (214,046) 1,562,419
Decrease in cash and cash equivalents (206,874) (179,475)
Cash and cash equivalents at beginning of year
480,851 660,326
Cash and cash equivalents at end of year 273,977 480,851
NOTES TO THE FINANCIAL STATEMENTS
1 General
The financial information set out above does not constitute the company's statutory accounts within the meaning of section 434 of the Companies Act 2006.
The 2009 figures are based on unaudited accounts for the year ended 30 June 2009. The auditors do not expect to issue a qualified report on the statutory accounts which will be finalised on the basis of the financial information presented by the directors in the preliminary announcement and which will be delivered to the Registrar of Companies following the company's annual general meeting.
The 2008 comparatives are derived from the statutory accounts for 2008 which have been delivered to the Registrar of Companies and received an unqualified audit report and did not contain a statement under the Companies Act 1985, s237(2) or (3).
This statement will be made available online at
2 Basis of accounting
The financial statements have been prepared under the historical cost convention and in accordance with International Financial Reporting Standards.
3 Loss per share
Basic loss per share is calculated by dividing the loss attributable to ordinary shareholders by 818.098 million being the weighted average number of ordinary shares outstanding during the period (2008: 598.110 million).
Diluted loss per share is calculated using the weighted average number of shares adjusted to assume the conversion of all dilutive potential ordinary shares.
4 Dividend
The Directors are not able to recommend a payment of a dividend.
5 Copies of the Report and Accounts
Copies of the report and accounts will be posted to those Shareholders that have requested them shortly. Copies are also available from the Company's registered office at 2a Langford Arch, London Road, Pampisford, Cambridgeshire CB22 3FX and from the Company's website www.sareum.co.uk.
This information is provided by RNS
The company news service from the London Stock Exchange
END
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| 19-10-09 | RNS |
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RNS Number : 0280B Sareum Holdings PLC 19 October 2009 19 October 2009 Sareum Holdings Plc ("Sareum" or "the Company") Holdings in Company The Company was notified today, following transactions on 15 October 2009, Barclays Stockbrokers Ltd holds 97,286,058 ordinary shares in the capital of the Company, equivalent to 8.28 per cent. of the issued share capital of the Company. Barclays Stockbrokers Ltd holds the shares on behalf of its clients. Enquiries:
Sareum Holdings plc
Merchant John East Securities Limited
Hybridan LLP
This information is provided by RNS The company news service from the London Stock Exchange END
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I am not sure I understand your post "He works in the city"
Lets assume you are correct and that he does. Well I know people that work in catering - they are still not chefs!!!! Lets assume you are wrong and he doesn't. Well he would post on the III message board. FACT! FACT number 2: No millionaires write books telling you how to become a millionaire the same way they did. FACT number 3 Neil is not mystic meg! More | View thread (1) | Respond | Login to Vote up | Login to Vote down |
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| Sat 18:43 | ||||
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"he works in the city" <- Lets hope he gets the sack then as its ppl like this f'ing the banks up! In response to the OP well the truth is no one knows what the upside of this is. If a deal was revealed then we would meet and who knows maybe break the broker target. If no deal happens soon then I think we can expect to see this fall to 0.2 over the next few months. I feel confident that we may hold 0.3 though due to speculation and reluctant sellers.
It is well worth nothing however that in 10 years this will be 2p LOL The reality is in 10 years this will either be history or multiple pounds, its a gamble all the way! More | View thread (7) | Respond | Login to Vote up | Login to Vote down |
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| Sat 18:42 | ||||
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"he works in the city" <- Lets hope he gets the sack then as its ppl like this f'ing the banks up! I responce to the OP well the truth is no onw knows what the upside of this is. If a deal was revealed then we would meet and who knows maybe break the broker prediction. If no deal happens soon then I think we can expect to see this fall to 0.2 over the next few months. I feel confident that we will hold 0.3 though due to speculation and reluctant sellers.
It is well worth nothing however that in 10 years this will be 2p LOL The reality is in 10 years this will either be history or multiple pounds, its a gamble all the way! More | View thread (7) | Respond | Login to Vote up | Login to Vote down |
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| Sat 00:31 | ||||
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he works in the city !!!!
More | View thread (7) | Respond | Login to Vote up | Login to Vote down |
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The contents of the postings summarised here represents the opinions of the authors and not of Interactive Investor Trading Limited.
They have not been approved or issued by Interactive Investor Trading Limited.
They have not been approved or issued by Interactive Investor Trading Limited.
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